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The already thin skin beneath the eyes may then allow blood vessels to become more visible, leading the skin to darken

10.7554/eLife.45807 Elife 21 BorrioneL.BelliniH.RazzaL.AvilaA.BaekenC.BremA.et al (2020)

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Kozakowska, M., Pietraszek-Gremplewicz, K., Jozkowicz, A

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Long-acting GLP-1 receptor agonists have little effect on gastric emptying due to the development of tolerance to GLP-1 effects mediated by changes in parasympathetic tone (Wettergren et al, 1998